大山達也

浜田勝光 arrow_blank.PNG 星野良太
所属豊橋技術科学大学
情報・知能工学専攻
学年博士課程3年
E-mail
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研究テーマ

  • 転写制御タンパク質ラクトースリプレッサーに作用するリガンドの特性解析
  • リガンドが結合したラクトースリプレッサーとDNA間の特異的相互作用の解析

研究業績

国際学術雑誌に発表した論文

  1. "Specific interactions between DNA and regulatory protein controlled by ligand-binding: Ab initio molecular simulation",
    Y. Matsushita, T. Murakawa, K. Shimamura, M. Oishi, T. Ohyama, N. Kurita,
    AIP conference proceedings, 2015, 1649, 121-129.
  2. "The effects of vitronectin on specific interactions between urokinase-type plasminogen activator and its receptor: Ab initio molecular orbital calculations",
    T. Kasumi, K. Araki, T. Ohyama, S. Tsuji, E. Yoshikawa, H. Kobayashi, N. Kurita,
    Molecular Simulation, 2013, in press.
  3. "Specific interactions and binding energies between thermolysin and potent inhibitors: Molecular simulations based on ab initio molecular orbital method",
    T. Hirakawa, S. Fujita, T. Ohyama, K. Dedachi, M. T. H. Khan, I. Sylte, N. Kurita,
    Journal of Molecular Graphics and Modelling, 2012, 33, 1-11.
  4. "Structure-based analysis of the molecular recognitions between HIV-1 TAR-RNA and transcription factor nuclear factor-kappaB (NFkB)",
    M. T. H. Khan, C. Mischiati, A. Ather, T. Ohyama, K. Dedachi, M. Borgatti, N. Kurita, R. Gambari,
    Journal Current Topics in Medicinal Chemistry, 2011, in press.
  5. "Specific interactions between lactose repressor protein and DNA affected by ligand binding: ab initio molecular orbital calculations",
    T. Ohyama, M. Hayakawa, S. Nishikawa, N. Kurita,
    Journal of Computational Chemistry, 2011, 32, 1661-1670.
  6. "Structure-based Analysis of the Molecular Recognitions between HIV-1 TAR-RNA and Transcription Factor NFkB",
    MTH, Khan, C. Mischiati, A. Ather, T. Ohyama, K. Dedachi, N. Kurita, R. Gambari,
    Cellular and Molecular Life Sciences, 2010, in press.
  7. "Ab initio fragment molecular orbital calculations on the specific interactions between human, mouse and rat PPARα and GW409544",
    M. Hayakawa, T. Ohyama, Y. Yamaguchi, S. Iwabuchi, T. Nakagawa, T. Nakajima, N. Kurita,
    Molecular Simulation, 2010, 36, 644-656.

国内の学術雑誌に発表した論文

...No achievement found.

国際学会における発表

  1. "Specific interactions between transcriptional regulatory protein and DNA: molecular simulations combined with MD and ab initio FMO methods",
    T. Ohyama, K. Nomura, N. Noriyuki,
    2nd AICS International Symposium, 2012, March 1-2, Kobe, Japan.
  2. "Analysis of specific interactions between transcriptional regulatory protein and DNA: molecular simulations combined with MD and ab initio FMO methods",
    T. Ohyama, K. Nomura, N. Kurita,
    52nd Sanibel Symposium, 2012, Feb. 19- Feb. 24, Georgia, U.S.A.
  3. "Allosteric effect on specific interaction between LacR and DNA induced by ligand-binding to LacR: molecular simulations combined with molecular dynamics and ab initio fragment molecular orbital methods"
    T. Ohyama, M. Hayakawa, S. Nishikawa, N. Kurita,
    51st Sanibel Symposium, 2011, Feb. 25- March 1, Georgia, U.S.A.
  4. "Specific interactions between lactose repressor protein and DNA affected by ligand binding: ab initio fragment molecular orbital calculations",
    T. Ohyama, M. Hayakawa, S. Nishikawa, N. Kurita,
    CBI Annual Meeting 2010, 2010, September 15-17, Tokyo, Japan.
  5. "Specific interactions between lactose repressor protein and its inducer and anti-inducer molecules as well as DNA: molecular mechanics and molecular orbital simulations",
    T. Ohyama, S. Nishikawa, Y. Sengoku and N. Kurita,
    International Symposium on Multi-scale Simulations of Biological and Soft Materials , 2008, June. 18-20, Tokyo, Japan.

国内学会における発表

  1. "分子シミュレーションによる転写制御タンパク質ラクトースリプレッサー二量体とDNA間の特異的相互作用の解析"
    大山達也, 松下祐貴, 栗田典之,
    第6回分子科学討論会, 2012, 東京都.
  2. "MD及びFMO 計算による転写制御タンパク質とDNA 間の特異的相互作用の解析",
    大山達也,野村和哉,栗田典之,
    第25回分子シミュレーション討論会, 2011, 東京都.
  3. "分子シミュレーションによるアロステリックタンパク質とDNA間の特異的相互作用の解析",
    大山達也, 野村和哉, 栗田典之,
    第5回分子科学討論会, 2011, 北海道.
  4. "転写制御タンパク質ラクトースリプレッサーとリガンド及びDNAとの特異的相互作用に関する高精度分子シミュレーション",
    大山達也, 西川真, 栗田典之,
    第3回分子科学討論会, 2009, 愛知県.
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